Jipmer pacs

Jipmer pacs

Email:drbiswajitdm gmail. Purpose: To study the late toxicities of treatment and its impact on Breast cancer survivors among Indian patients. Materials and Methods: Our study recruited curatively treated non metastatic carcinoma breast patients. The baseline demographic details, disease related and treatment related information were collected.

The late effects included breast cancer related lymphedema, shoulder dysfunction, treatment induced bone loss, hypothyroidism, cardiac dysfunction, and chemotherapy induced cognitive dysfunction and Quality of life. Results: The median age was 47 years range 27 years. The cumulative frequency of BCRL and shoulder dysfunction was The improvement in BCRL with corrective intervention was not statistically significant.

The BCRL was significantly associated with shoulder dysfunction. The frequency of loss of bone mineral density was There was statistically significant improvement in bone mineral density with interventions. The cumulative rate of hypothyroidism and cardiac dysfunction was We did not find any delayed cognitive dysfunction.

There was improvement in global health, physical function, role function, fatigue, Nausea, vomiting, pain scores, insomnia, Loss of appetite, diarrhea and arm symptoms over time with intervention.

Conclusion: Our study has shown that nearly half of the survivors were suffering from at least one of the late effects. The intervention helped in improving the loss of bone mineral density, hypothyroidism, cardiac dysfunction and quality of life in Breast cancer survivors.Elevated renin—angiotensin—aldosterone system RAAS activity is an important mechanism in the development of hypertension.

jipmer pacs

Both obesity and hydroxy vitamin D [25 OH D] deficiency have been associated with hypertension and augmented renin-angiotensin system RAS activity. We tried to test the hypothesis that vitamin D deficiency and obesity are associated with increased RAS activity in Indian patients with hypertension.

Fifty newly detected hypertensive patients were screened. Patients with secondary hypertension, chronic kidney disease, or coronary artery disease were excluded. Patients underwent measurement of vitamin D and plasma renin and plasma aldosterone concentrations.

A total of 50 male:female — patients were included, with a mean age of Mean systolic blood pressure SBP was Vitamin D supplementation along with weight loss may be studied as a therapeutic strategy to reduce tissue RAS activity in individualswith Vitamin D deficiency and obesity. Obesity is a state of relative vitamin D deficiency[ 1 ] and excess tissue renin angiotensin aldosterone system RAAS activity.

Li et al.

jipmer pacs

Cross-sectional human studies have also associated vitamin D deficiency with augmented RAAS activity, particularly in obesity. To ourknowledge, this is the first such study on Indian patients. All patients underwent a screening history and physical, laboratory examinations.

Patients with chronic kidney disease, coronary artery disease, heart failure or known causes of secondary hypertension were excluded. The study was approved by the hospital ethical committee and all the participants signed informed consent forms after being thoroughly explained about the study.

Measurement of serum 25 OH D was performed in all patients. Relationship between vitamin D levels and RAAS parameters in the overall study population was analyzed by Pearson correlation analysis. All the statistical analyses were performed using online GraphPad QuickCalc software. The study population's mean age was They were overweight with a BMI of The graph in Figure 1 demonstrates the mean blood pressure values as per the vitamin D levels. However, PAC levels maintained significant trend across the three groups.

Patients under group 1 were obese, whereas patients in groups 2 and 3 were overweight. The graph in Figure 2 demonstrates the mean blood pressure values as per the BMI. The 25 OH D levels did not vary significantly vary between overweight and obese subjects.

Although animal models strongly suggest that vitamin D suppresses the RAAS, there are limited human data supporting this hypothesis. Indian data in this respect are not available s far. We found that lower 25 OH D levels and higher BMI values were associated with higher plasma renin and aldosterone concentration in Indian subjects with hypertension.

Observational studies strongly support an inverse association between plasma 25 OH D levels and blood pressure and hypertension. In contrast, few human studies have examined this relationship. The first human study to investigate the association examined 10 normotensive individuals as well as 51 hypertensive individuals, on ambient diets, divided into low-renin, normal-renin, and high-renin status.

Continuing medical education programme on rational use of blood, its components

One randomized trial of vitamin D supplementation with ergocalciferol documented the effects on markers of the RAS. In addition, Ang II levels decreased by Though we did not take into consideration the sodium and calcium intake by our patients, we noticed significantly higher blood pressure among patients with lower serum 25 OH D levels in our study. Another study found out that among normotensive individuals in high sodium balance, lower plasma 25 OH D levels were associated with significantly higher circulating Ang II concentrations, as well as a blunted Renal plasma flow RPF response to infused Ang II.Named after the father of our nation Mahatma Gandhi, MGMCRI is head and shoulders above many a medical college in the country and continues to inspire the young and avid minds of prospective medical professionals.

A constituent College of Sri Balaji Vidyapeeth, Pondicherry a Health Sciences Deemed to be University, accredited by NAAC with A Grade in the First CycleMGMCRI offers a salubrious, yet academically challenging environment that boasts of an excellent reputation, synonymous with the availability of well qualified and experienced faculty, state-of-the-art infrastructure, well trained supportive staff, patient friendly health care team and above all eager, bright and discerning students who are ever ready to tread on their chosen path and profession with diligence, obedience, commitment, perseverance and dedication.

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To study the late toxicities of treatment and its impact on Breast cancer survivors among Indian patients. Our study recruited curatively treated non metastatic carcinoma breast patients. The baseline demographic details, disease related and treatment related information were collected.

The late effects included breast cancer related lymphedema, shoulder dysfunction, treatment induced bone loss, hypothyroidism, cardiac dysfunction, and chemotherapy induced cognitive dysfunction and Quality of life. The median age was 47 years range 27 years. The cumulative frequency of BCRL and shoulder dysfunction was The improvement in BCRL with corrective intervention was not statistically significant.

The BCRL was significantly associated with shoulder dysfunction. The frequency of loss of bone mineral density was There was statistically significant improvement in bone mineral density with interventions. The cumulative rate of hypothyroidism and cardiac dysfunction was We did not find any delayed cognitive dysfunction. There was improvement in global health, physical function, role function, fatigue, Nausea, vomiting, pain scores, insomnia, Loss of appetite, diarrhea and arm symptoms over time with intervention.

Our study has shown that nearly half of the survivors were suffering from at least one of the late effects. The intervention helped in improving the loss of bone mineral density, hypothyroidism, cardiac dysfunction and quality of life in Breast cancer survivors. Breast cancer BC is the commonest non dermatological malignancy among women globally Parkin et al. The incidence of BC is increasing in India and it has replaced carcinoma cervix as the most common malignancy among women in most of the cancer registries in India Das et al.

The current treatment of BC involves surgery with varying combinations of chemotherapy CTradiotherapy RTanti Her 2 neu treatment and hormonal treatment HT depending on the stage of the disease and other predictive parameters. In contrast to the developed nations, we have a huge burden of advanced breast cancers in India, which requires multimodality treatment.

The current advances in treatment have improved the outcome of patients diagnosed with BC. This improvement in outcome may be thwarted by the development of potential life threatening long term toxicities.Developing country, like India intestinal parasitic infections are still remaining as the most important health problem in public of concern.

The infection remains the most leading cause of morbidity and mortality especially among the childrens. It is presumed that the prevalence is high in developing countries probably due to poor sanitary conditions and improper personal hygiene practice.

The main aim of this study was carried to find out the prevalence of intestinal parasitic infection among rural and urban population of Puducherry, India.

This is a cross-sectional descriptive study carried out between the period September to December Random sampling was adopted to collect stool samples from urban and rural population in Puducherry. A door to door survey was done. The results were recorded, and data were presented in the form of frequency and distribution.

Among the rural and urban population, stool samples from the rural population showed nearly There was a noticeable male predominance pattern The increase in the prevalence of intestinal parasites among rural population than the urban population was statistically significant. The stool samples collected from rural population showed high prevalence of intestinal parasite infestation when compared to urban population, hence necessary interventions like health education, awareness creation and medical intervention should be undertaken particularly among the rural population.

In our study population, age group between years are predominantly infected with these parasites. Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. The other factors attributable to the prevalence of these infections are poverty, illiteracy, tropical hot and humid weather conditions and contaminated drinking water resources.

The enteric protozoan parasites and the soil-transmitted helminths are responsible for gastrointestinal disturbances leading to infections. Ascaris lumbricoides and Hymenolepis nana are the commonest nematode and cestode affecting approximately 1 billion people.

Intestinal parasitic infections are a major source of health concern in India like in any other developing nations. The overall prevalence of intestinal infections, caused by enteric parasites ranges from Limited studies determining the prevalence of intestinal parasitic infections have been published previously from South India. The studies related to the overall frequency of enteric parasites in the Union Territory of Puducherry have been scanty.

Therefore, this study was conducted to determine the present distribution pattern of the intestinal parasites among rural and urban communities in Puducherry, South India.

General Info

A geographic map showing the location of the rural and urban settings red dots involved in the study. This map was created using the Esri ArcMap All age groups, both the genders with symptomatic and asymptomatic were included in this study between September to December A random sampling was adopted to collect stool samples from urban and rural settings in Puducherry. The study was carried out between the period September to December The successive list of HODs from Equipments and services provided in the department.

The department is committed to excellence in patient care, education and contributes regularly to research activity from all specialties of the Institute. The department regularly conducts academic programmes and CMEs on its own as well as in collaboration with the Pondicherry subchapter of Tamilnadu and Pondicherry chapter of Indian radiological and Imaging Association.

The department of Radio-diagnosis offers quality diagnostic imaging services to all patients attending the main hospital, super specialty block, emergency medical services and regional cancer centre. General Info The department of Radio diagnosis was started in the year as the Department of Radiology comprising of the departments of Radio-diagnosis, Radiotherapy and Nuclear Medicine. The First officer of the Department of Radiology was Dr. The Department of Radiology separated into the departments of Radio-diagnosis and Radiotherapy in Currently, the Department is located in three blocks namely the main hospital block, super specialty block and emergency medical services.

There are 7 faculties in the department at present and the Head of Department is Dr.

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The successive list of HODs from K. Reddy Bhattacharya I. Dusaj K. Srivastava O. Sharma S.

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Elangovan S. Vivekanandam K. Patro K. Ramesh Since March till date. Equipments and services provided in the department Way back in ,the Department of Radio diagnosis had the following equipment mA X Ray machine, mA X Ray machine, mA battery operated mobile unit and Conventional fluoroscopy machine. At present, the department is equipped with Two state-of-the-art 1. Picture archiving and communication system PACS was installed in November which enables effortless and prompt viewing of all imaging investigations by the clinicians in their OPD, wards and work areas.

Vascular interventional radiology procedures were started since and various diagnostic as well as therapeutic interventional procedures such as bronchial artery and uterine artery embolization and preoperative tumor embolization, AVM embolization, chemoembolisation of liver tumors, coil placement, carotid stenting etc are being done since using the cardiac cath lab.

New full field digital mammography unit equipped with digital breast tomosynthesis and stereotactic biopsy device was installed in the department in April Percutaneous biliary drainage, sclerotherapy for varicose veins and Arteriovenous malformations are also being done regularly.

USG Elastography is also being done regularly for liver, breast and thyroid lesions. Contrast enhanced USG is being done recently for liver, renal and pancreatic lesions. Dedicated fetal anomaly scan is being done on regular basis by faculty on Tuesdays and Thursdays.Either your web browser doesn't support Javascript or it is currently turned off.

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In the latter case, please turn on Javascript support in your web browser and reload this page. To study the late toxicities of treatment and its impact on Breast cancer survivors among Indian patients. Our study recruited curatively treated non metastatic carcinoma breast patients.

jipmer pacs

The baseline demographic details, disease related and treatment related information were collected. The late effects included breast cancer related lymphedema, shoulder dysfunction, treatment induced bone loss, hypothyroidism, cardiac dysfunction, and chemotherapy induced cognitive dysfunction and Quality of life. The median age was 47 years range 27 years. The cumulative frequency of BCRL and shoulder dysfunction was The improvement in BCRL with corrective intervention was not statistically significant.

The BCRL was significantly associated with shoulder dysfunction. The frequency of loss of bone mineral density was There was statistically significant improvement in bone mineral density with interventions. The cumulative rate of hypothyroidism and cardiac dysfunction was We did not find any delayed cognitive dysfunction.

There was improvement in global health, physical function, role function, fatigue, Nausea, vomiting, pain scores, insomnia, Loss of appetite, diarrhea and arm symptoms over time with intervention. Our study has shown that nearly half of the survivors were suffering from at least one of the late effects.

The intervention helped in improving the loss of bone mineral density, hypothyroidism, cardiac dysfunction and quality of life in Breast cancer survivors. Breast cancer BC is the commonest non dermatological malignancy among women globally Parkin et al. The incidence of BC is increasing in India and it has replaced carcinoma cervix as the most common malignancy among women in most of the cancer registries in India Das et al.

The current treatment of BC involves surgery with varying combinations of chemotherapy CTradiotherapy RTanti Her 2 neu treatment and hormonal treatment HT depending on the stage of the disease and other predictive parameters. In contrast to the developed nations, we have a huge burden of advanced breast cancers in India, which requires multimodality treatment. The current advances in treatment have improved the outcome of patients diagnosed with BC.

This improvement in outcome may be thwarted by the development of potential life threatening long term toxicities. There is an increasing awareness about the delayed toxicities of cancer treatment and recently it has been extensively studied. The surviving patients are at higher risk of developing premature menopause, lymphedema of the arm, impaired shoulder mobility, loss of bone mineral density, cognitive impairment, cardiac dysfunction and hypothyroidism.

The long term follow up has also showed a significant increase in non-cancer morbidity and mortality, which is attributed to the toxicities of treatment. Unfortunately the late toxicities of treatment and its impact on BC survivors were not studied among Indian patients.

There is also a need to understand whether the late effects can be corrected and will this lead to an improvement in outcome. This study was a prospective cohort study. Written Informed Consent was taken from all subjects prior to the inclusion in the study.

The nature and importance of the study was explained to the subjects. The base line demographic details, disease related and treatment related information were collected from the case record.

The patients were evaluated for late effects of treatment and corrective interventions were administrated to those who were found to have late effects. The late effects were breast cancer related lymphedema BCRLshoulder dysfunction, treatment induced bone loss, hypothyroidism, cardiac dysfunction and chemotherapy induced cognitive dysfunction.

The patients were evaluated for BCRL with a measuring tape and the arm circumferences were measured at four fixed points. The points were 5 and 10 cm above and below the lateral epicondyle of the elbow joint. The measurements were done on both the upper limbs and any difference of 2 cm was recorded as lymph edema.


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